3D-MPLA-4A

Full Name: 3-O-deacylated-4'-monophosphoryl lipid A (3-DMPLA) Form: 4-acylated form, featuring a tetra-acyl carbon chain structure. Source: Derived from the Lipopolysaccharide (LPS) of Salmonella minnesota Re595.

Specifically engineered for immunological research, this variant is a key molecular probe for deciphering the Structure-Activity Relationship (SAR) of TLR4 receptors.Compared to the potent hexa-acyl (6A) version, the 4A variant exhibits minimal activity in human immune cells and functions as a potential TLR4 antagonist. It holds significant promise as a therapeutic lead for autoimmune and allergic diseases.