3D-MPLA-5A is a synthetic monophosphoryl lipid A (MPLA) analog/adjuvant used primarily in research involving innate immune activation, Toll-like receptor 4 (TLR4) signaling, vaccine adjuvant development, and immunology.
The “3D-MPLA” family generally refers to structurally defined, synthetic lipid-A-type molecules designed to reproduce selected immunostimulatory properties of lipid A while allowing controlled structural modification.
Why 3D-MPLA-5A is important
MPLA is derived from the lipid A portion of bacterial lipopolysaccharide (LPS). Compared with intact LPS, MPLA-type structures are designed to provide controlled TLR4-mediated immune stimulation with a substantially different inflammatory profile.
Synthetic 3D-MPLA compounds are particularly useful when researchers need:
- Well-defined chemical structures
- Reproducible TLR4/MD-2 stimulation
- Investigation of structure–activity relationships
- Development and optimization of vaccine adjuvants
- Studies of innate immune signaling
- Evaluation of lipid-based immunostimulatory formulations
Important specification note
The exact CAS number, molecular formula, molecular weight, chemical structure and purity specification for “3D-MPLA-5A” should be verified against the specific manufacturer's product specification/CoA. “3D-MPLA-5A” is a product/designation name rather than a universally standardized chemical name, and closely related 3D-MPLA analogs can have substantially different structures and molecular weights.
3D-MPLA-5A — Professional Technical Specification
ParameterSpecificationProduct Name3D-MPLA-5AFull Chemical Name3-Deacyl-Pentaacyl Monophosphoryl Lipid ASynonyms3D-MPLA-5A; 3D-MPL; 3-O-Deacyl-4′-monophosphoryl lipid A, penta-acylated form; 3-Deacyl-Pentaacyl Monophosphoryl Lipid ACAS No.220048-47-5Molecular FormulaC₈₂H₁₅₅N₂O₂₀PMolecular Weight1,520.09 g/molChemical ClassMonophosphoryl lipid A / lipid A derivativeAcylationPenta-acylated (5 fatty-acyl chains)Phosphate4′-monophosphateMolecular NatureAmphiphilic glycolipidBiological TargetTLR4/MD-2 signaling pathwaySource/OriginAssociated with lipid A/MPL chemistry derived from Salmonella minnesota R595/Re595 LPS; supplier-specific manufacturing route should be confirmedAppearanceWhite to off-white / pale yellow lyophilized powder or lipid solid*Purity≥98% by HPLC is reported for the referenced commercial material*Storage−20°C, protected from lightSolubilitySoluble/dispersible in suitable organic/lipid solvents such as ethanol or isopropanol; formulation-dependent*Recommended UseResearch use / vaccine-adjuvant and immunology researchTypical Pack Sizes5 mg, 10 mg, 50 mg or customized*
CAS and molecular data
The FDA GSRS record identifies 3-DEACYL-PENTAACYL MONOPHOSPHORYL LIPID A with:
- CAS: 220048-47-5
- Molecular formula: C₈₂H₁₅₅N₂O₂₀P
- Molecular weight: 1,520.09 g/mol
- PubChem substance identifier: 126480314
- FDA UNII: 48XF5E5EUK
3D-MPLA-5A — 3-Deacyl-Pentaacyl Monophosphoryl Lipid A
3D-MPLA-5A is a structurally defined penta-acylated derivative of monophosphoryl lipid A (MPLA), belonging to the lipid A family of immunostimulatory glycolipids. It contains a glucosamine-based lipid A backbone with a 4′-monophosphate group and five fatty-acyl chains, providing a defined molecular architecture for TLR4/MD-2 pathway research.
3D-MPLA-5A is designed for advanced research in vaccine adjuvant development, innate immunity, TLR4 signaling, immunology and lipid-based adjuvant formulation. Its defined penta-acylated structure makes it particularly valuable for investigating the relationship between lipid A acylation pattern and immune activity.
The product is suitable for research involving subunit vaccine platforms, liposomal adjuvant systems, structure–activity relationship studies and preclinical immunological evaluation. It can also be investigated in combination with other adjuvant components where appropriate for experimental formulation development.
Product Highlights:
• Penta-acylated 3D-MPLA structure
• Defined lipid A-derived immunostimulatory glycolipid
• TLR4/MD-2 pathway research reagent
• Suitable for vaccine-adjuvant and immunology research
• Appropriate for structure–activity and formulation studies
• Research-grade material with analytical purity specification
CAS No.: 220048-47-5
Molecular Formula: C₈₂H₁₅₅N₂O₂₀P
Molecular Weight: 1,520.09 g/mol
Purity: ≥98% HPLC*
Storage: −20°C, protected from light
*Actual purity, appearance, formulation and other quality parameters are subject to the specific batch Certificate of Analysis.
Applications
3D-MPLA-5A is relevant to:
- Vaccine adjuvant research
- Subunit vaccine development
- TLR4/MD-2 signaling studies
- Innate immune response research
- Immunology and cellular signaling studies
- Structure–activity relationship (SAR) studies of lipid A analogues
- Liposomal adjuvant formulations
- Combination-adjuvant research
- Preclinical vaccine research
- Investigation of MyD88/TRIF-associated TLR4 signaling
MPLA is a well-established TLR4-directed immunostimulatory platform, and 3D-MPLA represents a deacylated form designed to retain adjuvant activity while reducing the toxicity associated with native lipid
3D-MPLA-5A, 3D MPLA 5A, 3D-MPL, 3-Deacyl-Pentaacyl Monophosphoryl Lipid A, Pentaacyl Monophosphoryl Lipid A, 3-O-Deacyl Monophosphoryl Lipid A, MPLA, Monophosphoryl Lipid A, TLR4 agonist, TLR4 adjuvant, vaccine adjuvant, lipid A derivative
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