Active Ingredients:-
Full Name: 3-O-deacylated-4'-monophosphoryl lipid A (3-DMPLA) Form: 4-acylated form, featuring a tetra-acyl carbon chain structure. Source: Derived from the Lipopolysaccharide (LPS) of Salmonella minnesota Re595.
Product Applications:-
Specifically engineered for immunological research, this variant is a key molecular probe for deciphering the Structure-Activity Relationship (SAR) of TLR4 receptors.Compared to the potent hexa-acyl (6A) version, the 4A variant exhibits minimal activity in human immune cells and functions as a potential TLR4 antagonist. It holds significant promise as a therapeutic lead for autoimmune and allergic diseases.
Quality level:-
Research grade
3D-MPLA-4A is a 3-O-deacylated, 4-acylated monophosphoryl lipid A (MPLA) derivative. In the supplier nomenclature I found, it is a tetra-acyl form of 3D-MPLA, derived from Salmonella minnesota Re595 LPS and used primarily for TLR4 structure–activity and immunology research.
The important point is that 4A means four acyl chains, while 3D refers to 3-O-deacylation.
Biological significance
The number and arrangement of lipid A acyl chains strongly influence interaction with the TLR4/MD-2 receptor complex. Literature indicates that reducing lipid A acylation can substantially change TLR4 activity; tetra-acylated lipid A structures can behave very differently from the highly active hexa-acylated forms.
Therefore, 3D-MPLA-4A is particularly useful for studying:
- TLR4 structure–activity relationships (SAR)
- TLR4/MD-2 recognition
- Innate immune signaling
- Lipid A structure/function
- Immunomodulatory compounds
- Vaccine-adjuvant research
- Potential TLR4 agonist/antagonist behavior
One supplier specifically positions 3D-MPLA-4A for TLR4 receptor structure–activity research, rather than treating it simply as a conventional vaccine adjuvant.
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