Active Ingredients:-
Full Name: 3-O-deacylated-4'-monophosphoryl lipid A (3-DMPLA) Form: 3-acylated form, characterized by a tri-acyl carbon chain structure. Source: Derived from the Lipopolysaccharide (LPS) of Salmonella minnesota Re595.
Product Applications:-
Specifically designed for immunological research, particularly in exploring the Structure-Activity Relationship (SAR) of the TLR4 receptor.Compared to the potent 6-acyl (6A) version, the 3A variant exhibits minimal activity in human immune cells and possesses potential antagonistic properties. It serves as a promising candidate for therapeutic drug development in autoimmune and allergic diseases.
Quality level:-
Research grade
3D-MPLA-3A → TLR4/MD-2 recognition → innate immune activation → cytokine/co-stimulatory signaling → enhanced adaptive immune response
This makes compounds in this class particularly interesting for subunit, recombinant-protein, peptide and conjugate vaccine research, where the antigen itself may not generate a sufficiently strong immune response.
3D-MPLA-3A vs. traditional MPLA
MPLA (monophosphoryl lipid A) is derived from lipid A, the immunostimulatory portion of bacterial LPS. Structural modification can alter the balance between immune stimulation and inflammatory toxicity.
3D-MPLA-3A is therefore best understood as a defined synthetic/structurally modified TLR4-targeting adjuvant, rather than simply as conventional bacterial LPS.
For a product listing
For your Swasti Exports website/B2B catalogue, I would describe it more cautiously as:
3D-MPLA-3A – Synthetic TLR4 Agonist / Vaccine Adjuvant
3D-MPLA-3A is a synthetic lipid A–type immunostimulatory compound developed for research involving Toll-like receptor 4 (TLR4) signaling. It is intended for vaccine adjuvant research, immunological studies, and development of antigen-adjuvant formulations. Its defined chemical structure makes it useful for investigating innate immune activation and the enhancement of antigen-specific immune responses.
Important: The exact identity, CAS number, molecular formula, molecular weight and specifications should be verified against the particular manufacturer's datasheet because “3D-MPLA-3A” can refer to a specific proprietary/structural analog, and these details should not be guessed.
Research applications
Potential applications include:
- Vaccine adjuvant research
- Subunit vaccine development
- Recombinant-protein vaccine research
- TLR4 signaling studies
- Innate immune-response research
- Antigen–adjuvant formulation studies
- Immunology and inflammatory signaling research
Vaccine Adjuvant
Vaccine Adjuvant Research
Vaccine Development
Immunology Research
Innate Immunity
TLR4 Signaling
Toll Like Receptor 4
Immune Stimulation
Antigen Adjuvant Formulation
Subunit Vaccine Research
Recombinant Vaccine Research
Preclinical Vaccine Research
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